Vancomycin intermittent dosing calculator for infants aged
0-90
days
Please fill in all fields and press calculate to
see the result.
Intended use statement
The 'Vancomycin intermittent dosing calculator for infants aged 0-90
days' is a dosing calculator for individualised intermittent vancomycin dosing in
young infants and recommends the dose required to achieve the target
AUC24-48 of 400-650 mg/L·h
based on an individual’s post-menstrual age, weight,
and serum creatinine level.
This calculator is based on a published population pharmacokinetic model
(Gwee et al, JAMA Pediatrics 2019 173:8) and was validated in
a multicentre prospective clinical trial (Wilkins et al, Int J Antimicrob Agents 2023 61:3).
This calculator is intended for use in young infants aged
0 to 90
days with a post-menstrual age ≥ 25 weeks and weight ≥ 500
grams.
It has not been validated in young infants:
- with abnormal renal function, or
- those receiving extracorporeal membrane oxygenation or renal replacement therapy
This calculator is intended to be used alongside routine therapeutic drug monitoring.
Feedback?
Contact
kidscalc@mcri.edu.au